St. Louis Rams
| Kenneth Darby | RB | Illness | – |
| Jason Smith | T | Concussion | Out |
| Marc Bulger | QB | Knee | Out |
| Steven Jackson | RB | Back | Questionable |
| LaJuan Ramsey | DT | Wrist | Questionable |
| Mike Karney | RB | Neck | Questionable |
| Donnie Avery | WR | Shoulder | Probable |
| Kyle Boller | QB | Thigh | Probable |
| Brandon Gibson | WR | Ankle | Probable |
| James Laurinaitis | LB | Shoulder | Probable |
| Darell Scott | DT | Neck | Probable |
Tennessee Titans
| Tony Brown | DT | Not Injury Related | – |
| Kyle Vanden Bosch | DE | Not Injury Related | – |
| Jason Jones | DT | Shoulder | Out |
| Vince Young | QB | Knee | Questionable |
| Jared Cook | TE | Concussion | Questionable |
| Ahmard Hall | RB | Ankle | Questionable |
| Nicholas Harper | CB | Forearm | Questionable |
| Colin Allred | LB | Hamstring | Questionable |
| David Thornton | LB | Hip | Questionable |
| Kenny Britt | WR | Back | Probable |
| Chris Johnson | RB | Ankle | Probable |
| Nate Washington | WR | Ankle | Probable |