Indianapolis Colts
| Donald Brown | RB | Chest | Out |
| Aaron Francisco | CB | Ankle | Out |
| Anthony Gonzalez | WR | Knee | Out |
| Jerraud Powers | CB | Hamstring | Out |
| Adam Vinatieri | K | right Knee | Out |
| Dwight Freeney | DE | Abdomen | Questionable |
| Charlie Johnson | T | Foot | Questionable |
| Robert Mathis | DE | Quadricep | Questionable |
| Eric Foster | DT | Back | Questionable |
| Joseph Addai | RB | Knee | Probable |
| Antoine Bethea | CB | Foot | Probable |
| Gary Brackett | LB | Foot | Probable |
| Raheem Brock | DE | Back | Probable |
| Melvin Bullitt | CB | Shoulder | Probable |
| Keyunta Dawson | DE | Knee | Probable |
| Kyle DeVan | G | Shin | Probable |
| Ryan Diem | T | Hamstring | Probable |
| Pierre Garcon | WR | Knee | Probable |
| Kelvin Hayden | CB | Knee | Probable |
| Tim Jennings | CB | Ankle | Probable |
| Jacob Lacey | CB | Biceps | Probable |
| Peyton Manning | QB | Glute | Probable |
| Daniel Muir | DT | Hamstring | Probable |
| Jamey Richard | G | Shoulder | Probable |
| Tom Santi | TE | Hand | Probable |
| Clint Session | LB | Calf | Probable |
| Chad Simpson | RB | Back | Probable |
| Tony Ugoh | T | Hip | Probable |
| Reggie Wayne | WR | Foot | Probable |
Jacksonville Jaguars
| Greg Jones | RB | Ankle | Out |
| Clint Ingram | LB | Shoulder | Doubtful |
| Rashean Mathis | CB | Groin | Questionable |
| Derek Cox | CB | Ankle | Probable |
| Kynan Forney | G | Back | Probable |
| John Henderson | DT | Shoulder | Probable |
| Maurice Jones-Drew | RB | Knee | Probable |
| Zach Miller | TE | Shoulder | Probable |
| Mike Sims-Walker | WR | Calf | Probable |
| Daryl Smith | LB | Thigh | Probable |
| Julius Williams | DE | Knee | Probable |
Main Photo from UPI Photo/Mark Cowan