Arizona Cardinals
| Will Davis | LB | Knee | Out |
| Bert Berry | LB | Illness | Questionable |
| Kenny Iwebema | DE | Thumb | Questionable |
| Stephen Spach | TE | Knee | Questionable |
| Bryan Robinson | DT | Illness | Probable |
| Alan Branch | DT | Ankle | Probable |
| Mike Gandy | T | Pelvis | Probable |
| Tim Hightower | RB | Thumb | Probable |
| Dan Kreider | RB | Thigh | Probable |
| Jason Wright | RB | Illness | Probable |
| Ben Graham | P | left Groin | Probable |
| Neil Rackers | K | right Groin | Probable |
San Francisco 49ers
| Aubrayo Franklin | DT | Not Injury Related | – |
| Justin Smith | DT | Not Injury Related | – |
| Nate Clements | CB | Shoulder | Out |
| Isaac Bruce | WR | Ankle | Doubtful |
| Marcus Hudson | CB | Back | Questionable |
| Takeo Spikes | LB | Hamstring | Questionable |
| Joe Staley | T | Knee | Questionable |
| Brandon Jones | WR | Thumb | Probable |
| Michael Lewis | S | Quadricep | Probable |